The Hotel Regina Margherita - Cagliari sits in the middle of Cagliari, near the harbor zone and 1 km from the historic district. Though the hotel itself is on a residential street, guests will find shopping avenues on neighboring streets, along with numerous cafes. The Hotel Regina Margherita - Cagliari is 200 meters from the ferry port.

There are 100 rooms at the Hotel Regina Margherita - Cagliari, available as singles, doubles, or suites. Rooms have satellite television, Internet access, minibar, ironing sets, and en suite bathrooms. Some rooms have views of the ocean. Non-smoking rooms are available.

The Hotel Regina Margherita - Cagliari is a five floor modern property with a large foyer. The terrace at the hotel overlooks the Gulf of Cagliari. There is a morning breakfast, and Sardinian and Italian dishes are available from the main restaurant throughout the day. There are five conference rooms, supported with full technology, for up to 300 people. In the evenings, the bar serves drinks and snacks on the terrace. Parking is available to guests who arrive by car.